Denver Broncos vs San Francisco 49ers
NFL · Sun, Oct 4, 4:25 PM EDT
Original pick
Denver BroncosSpread (+2.5)-110on DraftKings
Confidence at pick time: 72/99 (Moderate)
Factors at pick time
+
Strong Record
14-3 overall (82% win rate)
+
Strong Road Team
6-2 on the road (75%)
+
Scoring Efficiency
Outscoring opponents by 90.0 PPG on the season
+
Opponent Injuries
San Francisco 49ers without Brandon Aiyuk (WR)
Frequently asked
What was SlateSense's pick for Denver Broncos vs San Francisco 49ers?
SlateSense picked Denver Broncos Spread (+2.5) at -110 with a confidence of 72/99.
When does Denver Broncos vs San Francisco 49ers start?
Denver Broncos vs San Francisco 49ers is scheduled for Sunday, October 4, 2026 (NFL). Times listed are ET.
How does SlateSense generate its picks?
SlateSense scores each side of every game across 50+ factors including team records, recent form, pitcher/goalie matchups, line movement, weather, injuries, rest, advanced metrics (run differential, net rating, etc.), and market disagreement. The model picks the side with the larger factor score when the gap is meaningful.
See every pick across every sport
Sign up free for the full slate, save bets to track your ROI, and ask Sharp AI about any parlay.
Create Free AccountUpdated every 15 minutes. Always do your own research.