Detroit Lions vs Buffalo Bills

NFL · Thu, Sep 17, 8:15 PM EDT

AI Pick
Buffalo BillsSpread-3-105on BetMGM
Confidence 87/99 (Strong)Market prob 58.8%Edge 7.6%
Why this pick

Buffalo Bills have 6 factors working in their favor: 12-5 overall (71% win rate). 7-2 at home (78%). Outscoring opponents by 116.0 PPG on the season. The tight -3-point spread indicates a close game despite being favored.

Factors driving the pick
+
Strong Record
12-5 overall (71% win rate)
+
Home Dominance
7-2 at home (78%)
+
Scoring Efficiency
Outscoring opponents by 116.0 PPG on the season
+
Record Advantage
Significantly better record than Detroit Lions (71% vs 53%)
+
Opponent Injuries
Detroit Lions without Kendrick Law (WR)
+
Home Field
Playing at home — crowd, routine, and familiarity advantage
Best lines available
-105
BetMGM
-106
BetRivers
-110
DraftKings
-110
Caesars
-110
Bovada

Frequently asked

What is SlateSense's pick for Detroit Lions vs Buffalo Bills?

SlateSense's AI model picks Buffalo Bills Spread (-3) at -105 on BetMGM, with a confidence of 87/99 (Strong).

When does Detroit Lions vs Buffalo Bills start?

Detroit Lions vs Buffalo Bills is scheduled for Thursday, September 17, 2026 (NFL). Times listed are ET.

What are the best odds for Buffalo Bills Spread (-3)?

Best available: BetMGM (-105), BetRivers (-106), DraftKings (-110).

How does SlateSense generate its picks?

SlateSense scores each side of every game across 50+ factors including team records, recent form, pitcher/goalie matchups, line movement, weather, injuries, rest, advanced metrics (run differential, net rating, etc.), and market disagreement. The model picks the side with the larger factor score when the gap is meaningful.

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