Minnesota Vikings vs San Francisco 49ers
NFL · Sun, Nov 22, 8:20 PM EST
Original pick
San Francisco 49ersMoneyline-198on DraftKings
Confidence at pick time: 93/99 (Strong)
Factors at pick time
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Strong Record
12-5 overall (71% win rate)
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Scoring Efficiency
Outscoring opponents by 66.0 PPG on the season
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Record Advantage
Significantly better record than Minnesota Vikings (71% vs 53%)
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Home Field
Playing at home — crowd, routine, and familiarity advantage
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Steam on Pick
Spread moved 1.0 points toward this side since opening — sharp money agrees
Frequently asked
What was SlateSense's pick for Minnesota Vikings vs San Francisco 49ers?
SlateSense picked San Francisco 49ers Moneyline at -198 with a confidence of 93/99.
When does Minnesota Vikings vs San Francisco 49ers start?
Minnesota Vikings vs San Francisco 49ers is scheduled for Sunday, November 22, 2026 (NFL). Times listed are ET.
How does SlateSense generate its picks?
SlateSense scores each side of every game across 50+ factors including team records, recent form, pitcher/goalie matchups, line movement, weather, injuries, rest, advanced metrics (run differential, net rating, etc.), and market disagreement. The model picks the side with the larger factor score when the gap is meaningful.
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